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| Review Cart Language English Deutsch Español Italiano Français Products MSM Oral MSM Solution MSM Crystals Topical MSM Gel Bulk MSM Crystals EXCELSA EXCELSA Solution EXCELSA Solution 10X EXCELSA Gel EXCELSA Gel 20X DMSO 99.98% Pure DMSO 90% DMSO Solution 90% DMSO Gel 70% DMSO Solution 70% DMSO Gel 50% DMSO Solution 50% DMSO Gel 25% DMSO Gel DUSA 60 DUSA SAL Information About Us Resources General Information Privacy Policy |
These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. These statements have been provided by Dr. Stanley W. Jacob. 
What is DMSO? Dimethyl
Dimethyl sulfoxide (DMSO) was first synthesized in 1866, has been available as
a by-product of the paper pulp industry for many years, and is now used chiefly
as an industrial solvent. In 1964 Dr. Stanley W. Jacob, et al. first described the
remarkable medicinal properties of DMSO. When applied to intact human skin, the compound
penetrates rapidly and produces a wide range of pharmacologic actions, including
antiinflammation, local analgesia, bacteriostasis, diuresis, cholinesterase inhibition,
enhancement of the action of concomitantly administered drugs, influence on collagen,
nonspecific enhancement of immunity, vasodilation, and lessening of adhesiveness of blood
platelets. As a result the compound has been used widely as a treatment for various conditions,
including arthritis, bursitis, acute musculoskeletal trauma, scleroderma, troublesome
urogenital disorders, and various postoperative pain syndromes. To date little,
if any, local or systemic toxicity has been noted in humans after the administration of DMSO.
How does DMSO work?
Research suggests the eight primary pharmacologic actions of dimethyl sulfoxide are:
Does MSM have the same biological effects as DMSO?
Research suggests MSM produces many-but not all-of the DMSO effects. The following are
considered MSM's most significant actions:
How else does MSM differ from DMSO?
One of the factors that set both DMSO and MSM apart is that they are small molecules. DMSO tips
the scales at a molecular weight of 78; MSM, 94. By chemistry standards, they are featherweight
molecules. They mimic water in this respect. Water has a very low molecular weight and
passes through tissue. DMSO and MSM pass through the skin and into the tissue below. Just
like DMSO, MSM is very useful when employed as a topical gel, cream, or lotion to help in the
relief of local pain and inflammation. Unlike DMSO, however, MSM cannot transport medication with it.Another difference between the two compounds is that DMSO is a proven and powerful free-radical scavenger, that is, an antioxidant, whereas MSM's is not a free radical scavenger. Free radicals are unstable molecular fragments that launch an oxidative attack on DNA, cell membranes, enzymes, and proteins, disrupting normal cellular activities and triggering the inflammatory process. Such cumulative oxidative damage is similar to the rusting of metal and contributes to premature aging and the development of serious disease. Every disease known to medical science is associated with an increased activity of free radicals.
Is MSM a safe compound?
One of the first things we set out to learn about MSM was its safety. In long-term toxicity trials
with laboratory animals we found no toxic effects with oral doses of 8 grams per kilogram (2.2
pounds) of body weight. Most people take from 2 to 8 grams total as a daily supplement. To determine
the lethal dose of MSM, or of any substance, we used a standard test known as LD-50. LD stands for
lethal dose. The number 50 refers to the amount of the substance required that would result in the
death of half the number of laboratory animals used in the test. For MSM, the findings determined
that the LD-50 was more than 20 grams for each kilogram of body weight. To put that into perspective,
the LD-50 of common table salt you use for cooking is 2.5 to 3 grams per kilogram of weight. MSM thus
rates as one of the least toxic substances in biology and medicine. It compares to water, which has
an LD-50 rating also greater than 20 grams per kilogram of weight. In follow-up experiments with
human volunteers, we found no toxic effects at intake levels of up to 1 gram per kilogram of body
weight per day for 30 days. That means about 68 grams for an average 150-pound person. A few patients
have taken more than 100 grams orally of MSM daily without any side effects. But these were extremely
unusual cases involving very sick patients under Dr. Jacob's personal care. Do not take that much on
your own. Please consult your health care professional for details on how much MSM to take.
Is MSM a natural compound?
In its natural state MSM is an inconspicuous sulfur molecule found in the atmosphere, in plants,
animals, and the human body. Chemically, it consists of two hydrocarbon units (groups of hydrogen
and carbon atoms) attached to a unit with one sulfur and two oxygen atoms. The molecule is one-third
sulfur by weight. Atmospheric chemists describe the molecule as a minor oxidation product in an oceanic
sulfur cycle that begins with marine algae. These ocean organisms, called phytoplankton, release sulfur
compounds known as dimethylsulfonium salts. The salts, in turn, are transformed in the ocean water
into a volatile compound- dimethylsulfide (DMS)-which escapes as a gas from watery depths and rises
into the atmosphere. There, the DMS undergoes photochemical oxidation and is converted to sulfur
compounds, mostly sulfates, and, in part, to DMSO2 (MSM) as well as dimethyl sulfoxide (DMSO), the
closest relative of MSM. These compounds are absorbed in tiny droplets called aerosols that float
around the atmosphere and are returned to the surface of the ocean with rainwater.On land, a number of scientific analyses over the years have found MSM present naturally in animal tissue, food, and in the human body. Researchers first discovered the molecule more than fifty years ago in the blood, adrenal glands, and milk of cows. It was also found to be present in horses and rabbits and assumably is there in other species. Later, in a 1982 analysis by the Crown-Zellerbach Company, milk was found to contain between 2 and 6 parts per million of MSM. That may not seem like much but the quantity is higher than the level of some other better-known minerals, such as manganese and selenium. Zinc, by comparison, weighs in at 8.6 parts per million in milk. Coffee contains about 1.5 parts of MSM per million, and tea somewhat less. Green vegetables and other foods have small traces of MSM. MSM's presence in the human body was first reported during the 1960s, when a laboratory analysis of the urine of men, women, and children found that 4 to 11 milligrams of MSM was excreted over a twenty-four-hour period. Then in the late 1980s, a researcher at a major German pharmaceutical company found that MSM is present in human plasma. Plasma is the liquid part of blood. Through a gas chromatography technique, W. Martin of Pharmakin Gmbh of Ulm detected a "significant concentration" of MSM among the one hundred samples of plasma he examined. He found the equivalent of about 4 milligrams of MSM in the plasma of an average-size adult. So far, researchers have not adequately been able to explain the presence of MSM other than that it comes from food sources and/or is the result of a natural chain of biochemical reactions. Its precise role is not known. The studies to date are tantalizing but preliminary. More are needed. Hopefully, this information will promote further research necessary to understand better this unique and natural substance that perpetuates a long sulfur healing tradition. These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. These statements have been provided by Dr. Stanley W. Jacob. |
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